Biodegradable Thermoplastic Starch/Polycaprolactone Blends with Co-Continuous Morphology Suitable for Local Release of Antibiotics

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dc.contributor.authorGajdošová, Veronikacs
dc.contributor.authorStrachota, Beatacs
dc.contributor.authorStrachota, Adamcs
dc.contributor.authorMichálková, Danušecs
dc.contributor.authorKrejčíková, Sabinacs
dc.contributor.authorFulin, Petrcs
dc.contributor.authorNyč, Otakarcs
dc.contributor.authorBřínek, Adamcs
dc.contributor.authorZemek, Marekcs
dc.contributor.authorŠlouf, Miroslavcs
dc.coverage.issue3cs
dc.coverage.volume15cs
dc.date.accessioned2022-06-03T14:56:47Z
dc.date.available2022-06-03T14:56:47Z
dc.date.issued2022-01-30cs
dc.description.abstractWe report a reproducible preparation and characterization of highly homogeneous thermoplastic starch/pol(epsilon-caprolactone) blends (TPS/PCL) with a minimal thermomechanical degradation and co-continuous morphology. These materials would be suitable for biomedical applications, specifically for the local release of antibiotics (ATB) from the TPS phase. The TPS/PCL blends were prepared in the whole concentration range. In agreement with theoretical predictions based on component viscosities, the co-continuous morphology was found for TPS/PCL blends with a composition of 70/30 wt.%. The minimal thermomechanical degradation of the blends was achieved by an optimization of the processing conditions and by keeping processing temperatures as low as possible, because higher temperatures might damage ATB in the final application. The blends' homogeneity was verified by scanning electron microscopy. The co-continuous morphology was confirmed by submicron-computed tomography. The mechanical performance of the blends was characterized in both microscale (by an instrumented microindentation hardness testing; MHI) and macroscale (by dynamic thermomechanical analysis; DMTA). The elastic moduli of TPS increased ca four times in the TPS/PCL (70/30) blend. The correlations between elastic moduli measured by MHI and DMTA were very strong, which implied that, in the future studies, it would be possible to use just micromechanical testing that does not require large specimens.en
dc.formattextcs
dc.format.extent1-22cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationMaterials . 2022, vol. 15, issue 3, p. 1-22.en
dc.identifier.doi10.3390/ma15031101cs
dc.identifier.issn1996-1944cs
dc.identifier.other177480cs
dc.identifier.urihttp://hdl.handle.net/11012/204576
dc.language.isoencs
dc.publisherMDPIcs
dc.relation.ispartofMaterialscs
dc.relation.urihttps://www.mdpi.com/1996-1944/15/3/1101cs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/1996-1944/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectthermoplastic starchen
dc.subjectpoly(epsilon-caprolactone)en
dc.subjectpolymer blendsen
dc.subjectmicromechanical propertiesen
dc.subjectmicroindentationen
dc.subjectstructure-properties relationsen
dc.titleBiodegradable Thermoplastic Starch/Polycaprolactone Blends with Co-Continuous Morphology Suitable for Local Release of Antibioticsen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-177480en
sync.item.dbtypeVAVen
sync.item.insts2022.06.03 16:56:46en
sync.item.modts2022.06.03 16:14:15en
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Pokročilé instrumentace a metody pro charakterizace materiálůcs
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Pokročilé instrumentace a metody pro charakterizace materiálů