A novel biocompatible titanium–gadolinium quantum dot as a bacterial detecting agent with high antibacterial activity

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dc.contributor.authorSur, Vishma Pratapcs
dc.contributor.authorMazumdar, Anindacs
dc.contributor.authorAmirmansoor, Ashrafics
dc.contributor.authorMukherjee, Atripancs
dc.contributor.authorMilosavljević, Vedrancs
dc.contributor.authorMichálková, Hanacs
dc.contributor.authorKopel, Pavelcs
dc.contributor.authorRichtera, Lukášcs
dc.contributor.authorMoulick, Amitavacs
dc.coverage.issue4cs
dc.coverage.volume10cs
dc.date.accessioned2020-08-04T11:58:01Z
dc.date.available2020-08-04T11:58:01Z
dc.date.issued2020-04-17cs
dc.description.abstractIn this study, the titanium gadolinium quantum dots (TGQDs) were novel, first of its type to be synthesized, and fully characterized to date. Multiple physical characterization includes scanning electron microscopy (SEM), scanning electrochemical microscope (SCEM), x-ray fluorescence, spectrophotometry, and dynamic light scattering were carried out. The obtained results confirmed appropriate size and shape distributions in addition to processing optical features with high quantum yield. The synthesized TGQD was used as a fluorescent dye for bacterial detection and imaging by fluorescent microscopy and spectrophotometry, where TGQD stained only bacterial cells, but not human cells. The significant antibacterial activities of the TGQDs were found against a highly pathogenic bacterium (Staphylococcus aureus) and its antibiotic resistant strains (vancomycin and methicillin resistant Staphylococcus aureus) using growth curve analysis and determination of minimum inhibitory concentration (MIC) analysis. Live/dead cell imaging assay using phase-contrast microscope was performed for further confirmation of the antibacterial activity. Cell wall disruption and release of cell content was observed to be the prime mode of action with the reduction of cellular oxygen demand (OD).en
dc.formattextcs
dc.format.extent1-18cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationNanomaterials. 2020, vol. 10, issue 4, p. 1-18.en
dc.identifier.doi10.3390/nano10040778cs
dc.identifier.issn2079-4991cs
dc.identifier.other164383cs
dc.identifier.urihttp://hdl.handle.net/11012/191379
dc.language.isoencs
dc.publisherMDPIcs
dc.relation.ispartofNanomaterialscs
dc.relation.urihttps://www.mdpi.com/2079-4991/10/4/778cs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/2079-4991/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectbacterial resistanceen
dc.subjecttitanium-gadolinium quantum dotsen
dc.subjectbacterial detectionen
dc.subjectantibacterial activityen
dc.subjectSECMen
dc.titleA novel biocompatible titanium–gadolinium quantum dot as a bacterial detecting agent with high antibacterial activityen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-164383en
sync.item.dbtypeVAVen
sync.item.insts2020.12.07 16:55:53en
sync.item.modts2020.12.07 16:14:21en
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Chytré nanonástrojecs
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