Influence of Hydroxyapatite Nanoparticles and Surface Plasma Treatment on Bioactivity of Polycaprolactone Nanofibers

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dc.contributor.authorŠťastná, Evacs
dc.contributor.authorČástková, Kláracs
dc.contributor.authorRáheĺ, Jozefcs
dc.coverage.issue9cs
dc.coverage.volume12cs
dc.date.accessioned2020-10-29T10:05:47Z
dc.date.available2020-10-29T10:05:47Z
dc.date.issued2020-08-20cs
dc.description.abstractNanofibers are well known as a beneficial type of structure for tissue engineering. As a result of the high acquisition cost of the natural polymers and their environmentally problematic treatment (toxic dissolution agents), artificial polymers seem to be the better choice for medical use. In the present study, polycaprolactone nano-sized fibrous structures were prepared by the electrospinning method. The impact of material morphology (random or parallelly oriented fibers versus continuous layer) and the presence of a fraction of hydroxyapatite nanoparticles on cell proliferation was tested. In addition, the effect of improving the material wettability by a low temperature argon discharge plasma treatment was evaluated, too. We have shown that both hydroxyapatite particles as well as plasma surface treatment are beneficial for the cell proliferation. The significant impact of both influences was evident during the first 48 h of the test: the hydroxyapatite particles in polycaprolactone fibers accelerated the proliferation by 10% compared to the control, and the plasma-treated ones enhanced proliferation by 30%.en
dc.formattextcs
dc.format.extent1-16cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationPolymers. 2020, vol. 12, issue 9, p. 1-16.en
dc.identifier.doi10.3390/polym12091877cs
dc.identifier.issn2073-4360cs
dc.identifier.other164786cs
dc.identifier.urihttp://hdl.handle.net/11012/194808
dc.language.isoencs
dc.publisherMDPIcs
dc.relation.ispartofPolymerscs
dc.relation.urihttps://www.mdpi.com/2073-4360/12/9/1877cs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/2073-4360/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectelectrospinningen
dc.subjectnanofibersen
dc.subjectpolycaprolactoneen
dc.subjecthydroxyapatiteen
dc.subjecttissue engineeringen
dc.subjectatmospheric pressure argon plasmaen
dc.titleInfluence of Hydroxyapatite Nanoparticles and Surface Plasma Treatment on Bioactivity of Polycaprolactone Nanofibersen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-164786en
sync.item.dbtypeVAVen
sync.item.insts2021.01.12 16:54:59en
sync.item.modts2021.01.12 16:14:40en
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Pokročilé keramické materiálycs
thesis.grantorVysoké učení technické v Brně. Fakulta strojního inženýrství. Ústav materiálových věd a inženýrstvícs
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