Changes in Phonation and Their Relations with Progress of Parkinson’s Disease

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dc.contributor.authorGaláž, Zoltáncs
dc.contributor.authorMekyska, Jiřícs
dc.contributor.authorZvončák, Vojtěchcs
dc.contributor.authorMucha, Jáncs
dc.contributor.authorKiska, Tomášcs
dc.contributor.authorSmékal, Zdeněkcs
dc.contributor.authorEliášová, Ilonacs
dc.contributor.authorMráčková, Martinacs
dc.contributor.authorKošťálová, Miroslavacs
dc.contributor.authorRektorová, Irenacs
dc.contributor.authorFaúndez Zanuy, Marcoscs
dc.contributor.authorAlonso-Hernandez, Jesuscs
dc.contributor.authorGomez-Vilda, Pedrocs
dc.coverage.issue12cs
dc.coverage.volume8cs
dc.date.accessioned2020-08-04T11:00:02Z
dc.date.available2020-08-04T11:00:02Z
dc.date.issued2019-01-22cs
dc.description.abstractHypokinetic dysarthria, which is associated with Parkinson’s disease (PD), affects several speech dimensions, including phonation. Although the scientific community has dealt with a quantitative analysis of phonation in PD patients, a complex research revealing probable relations between phonatory features and progress of PD is missing. Therefore, the aim of this study is to explore these relations and model them mathematically to be able to estimate progress of PD during a two-year follow-up. We enrolled 51 PD patients who were assessed by three commonly used clinical scales. In addition, we quantified eight possible phonatory disorders in five vowels. To identify the relationship between baseline phonatory features and changes in clinical scores, we performed a partial correlation analysis. Finally, we trained XGBoost models to predict the changes in clinical scores during a two-year follow-up. For two years, the patients’ voices became more aperiodic with increased microperturbations of frequency and amplitude. Next, the XGBoost models were able to predict changes in clinical scores with an error in range 11–26%. Although we identified some significant correlations between changes in phonatory features and clinical scores, they are less interpretable. This study suggests that it is possible to predict the progress of PD based on the acoustic analysis of phonation. Moreover, it recommends utilizing the sustained vowel /i/ instead of /a/.en
dc.formattextcs
dc.format.extent1-18cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationApplied Sciences - Basel. 2019, vol. 8, issue 12, p. 1-18.en
dc.identifier.doi10.3390/app8122339cs
dc.identifier.issn2076-3417cs
dc.identifier.other151772cs
dc.identifier.urihttp://hdl.handle.net/11012/137247
dc.language.isoencs
dc.publisherMDPIcs
dc.relation.ispartofApplied Sciences - Baselcs
dc.relation.urihttps://www.mdpi.com/2076-3417/8/12/2339cs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/2076-3417/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectphonationen
dc.subjectacoustic analysisen
dc.subjectfollow-up studyen
dc.subjecthypokinetic dysarthriaen
dc.subjectParkinson’s diseaseen
dc.titleChanges in Phonation and Their Relations with Progress of Parkinson’s Diseaseen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-151772en
sync.item.dbtypeVAVen
sync.item.insts2020.08.04 13:00:02en
sync.item.modts2020.08.04 12:41:49en
thesis.grantorVysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií. oddělení-TKO-SIXcs
thesis.grantorVysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií. Ústav telekomunikacícs
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