High-throughput deposition of chemical reagents via pen-plotting technique for microfluidic paper-based analytical devices

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dc.contributor.authorRahbar, Mohammadcs
dc.contributor.authorNesterenko, Pavelcs
dc.contributor.authorPaull, Brettcs
dc.contributor.authorMacka, Miroslavcs
dc.coverage.issue1cs
dc.coverage.volume1047cs
dc.date.accessioned2020-08-04T11:03:42Z
dc.date.available2020-08-04T11:03:42Z
dc.date.issued2019-01-24cs
dc.description.abstractThe deposition of chemical reagent inks on paper is a crucial step in the development and fabrication of microfluidic paper-based analytical devices (mu PADs). A pen-plotting approach, delivering chemical ink deposition using technical pens filled with reagents and inserted into a desktop electronic plotter, is shown herein to be a versatile, low-cost, simple, rapid, reproducible, and high-throughput solution. The volume of the deposited ink was quantified gravimetrically, confirming that nanoliter volumes of reagents can be deposited reproducibly (e.g. 7.55 +/- 0.37 nL/mm for a plotting speed of 10 cm/s) in detection zones of mu PADs, typically spatially defined using wax printing. This approach was further investigated with regard to deposition of reagents in different geometrical forms (circular and linear), so demonstrating its applicability for preparation of mu PADs with flexible design and application. By adjusting the plotting speed for linear deposition, lines with a relatively large range of widths (approximate to 628-1192 mm) were created. Circular deposition was also demonstrated via delivery of reagents within wax printed circular fluidic barriers of a range of diameters (inner diameter = 1.5-7 mm). These capabilities were practically demonstrated via the fabrication of mu PADs, based upon differing detection principles for determination of aluminum in natural waters using Morin as the fluorescent reagent. Traditional mu PADs based on digital image colorimetry (DIC) were produced using circular deposition, whilst distance-based mu PADs exploited linear deposition. Both types of mu PADs developed using this method showed excellent precision for determination of trace concentrations of aluminium (average RSDs = 3.38% and 6.45%, and LODs = 0.5 ng (0.25 ppm) and 2 ng (0.5 ppm), for traditional and distance-based detection, respectively).en
dc.formattextcs
dc.format.extent115-123cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationANALYTICA CHIMICA ACTA. 2019, vol. 1047, issue 1, p. 115-123.en
dc.identifier.doi10.1016/j.aca.2018.09.006cs
dc.identifier.issn0003-2670cs
dc.identifier.other156231cs
dc.identifier.urihttp://hdl.handle.net/11012/138386
dc.language.isoencs
dc.publisherElseviercs
dc.relation.ispartofANALYTICA CHIMICA ACTAcs
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S000326701831064Xcs
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivatives 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/0003-2670/cs
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/cs
dc.subjectMicrofluidic paper-based analytical deviceen
dc.subjectReagent depositionen
dc.subjectTechnical penen
dc.subjectPlotteren
dc.subjectDistance-based detectionen
dc.subjectAluminium determinationen
dc.titleHigh-throughput deposition of chemical reagents via pen-plotting technique for microfluidic paper-based analytical devicesen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-156231en
sync.item.dbtypeVAVen
sync.item.insts2020.08.04 13:03:42en
sync.item.modts2020.08.04 12:24:04en
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Chytré nanonástrojecs
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