Nerve-associated Schwann cell precursors contribute extracutaneous melanocytes to the heart, inner ear, supraorbital locations and brain meninges

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dc.contributor.authorKaucká, Markétacs
dc.contributor.authorSzarowská, Báracs
dc.contributor.authorKavková, Michaelacs
dc.contributor.authorKastriti, Maria Elenics
dc.contributor.authorKameneva, Polinacs
dc.contributor.authorSchmidt, Ingacs
dc.contributor.authorPešková, Luciecs
dc.contributor.authorJoven Araus, Albertocs
dc.contributor.authorSimon, Andrascs
dc.contributor.authorKaiser, Jozefcs
dc.contributor.authorAdameyko, Igorcs
dc.coverage.issue14cs
dc.coverage.volume78cs
dc.date.accessioned2021-12-01T15:56:46Z
dc.date.available2021-12-01T15:56:46Z
dc.date.issued2021-07-18cs
dc.description.abstractMelanocytes are pigmented cells residing mostly in the skin and hair follicles of vertebrates, where they contribute to colouration and protection against UV-B radiation. However, the spectrum of their functions reaches far beyond that. For instance, these pigment-producing cells are found inside the inner ear, where they contribute to the hearing function, and in the heart, where they are involved in the electrical conductivity and support the stiffness of cardiac valves. The embryonic origin of such extracutaneous melanocytes is not clear. We took advantage of lineage-tracing experiments combined with 3D visualizations and gene knockout strategies to address this long-standing question. We revealed that Schwann cell precursors are recruited from the local innervation during embryonic development and give rise to extracutaneous melanocytes in the heart, brain meninges, inner ear, and other locations. In embryos with a knockout of the EdnrB receptor, a condition imitating Waardenburg syndrome, we observed only nerve-associated melanoblasts, which failed to detach from the nerves and to enter the inner ear. Finally, we looked into the evolutionary aspects of extracutaneous melanocytes and found that pigment cells are associated mainly with nerves and blood vessels in amphibians and fish. This new knowledge of the nerve-dependent origin of extracutaneous pigment cells might be directly relevant to the formation of extracutaneous melanoma in humans.en
dc.formattextcs
dc.format.extent6033-6049cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationCellular and Molecular Life Sciences. 2021, vol. 78, issue 14, p. 6033-6049.en
dc.identifier.doi10.1007/s00018-021-03885-9cs
dc.identifier.issn1420-9071cs
dc.identifier.other172051cs
dc.identifier.urihttp://hdl.handle.net/11012/203036
dc.language.isoencs
dc.publisherSpringercs
dc.relation.ispartofCellular and Molecular Life Sciencescs
dc.relation.urihttps://link.springer.com/article/10.1007%2Fs00018-021-03885-9cs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/1420-9071/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectExtracutaneous pigment cellen
dc.subjectTargeted recruitmenten
dc.subjectEndothelin 3 and endothelin receptor Ben
dc.subjectGlial precursoren
dc.subjectPeripheral nervesen
dc.subjectHypopigmentation-associated deafnessen
dc.titleNerve-associated Schwann cell precursors contribute extracutaneous melanocytes to the heart, inner ear, supraorbital locations and brain meningesen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-172051en
sync.item.dbtypeVAVen
sync.item.insts2021.12.01 16:56:46en
sync.item.modts2021.12.01 16:15:50en
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Pokročilé instrumentace a metody pro charakterizace materiálůcs
thesis.grantorVysoké učení technické v Brně. Fakulta strojního inženýrství. Ústav fyzikálního inženýrstvícs
thesis.grantorVysoké učení technické v Brně. Ústav soudního inženýrství. Ústav soudního inženýrstvícs
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