Effect of increased left ventricle mass on ischemia assessment in electrocardiographic signals: rabbit isolated heart study

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dc.contributor.authorRonzhina, Marinacs
dc.contributor.authorOlejníčková, Veronikacs
dc.contributor.authorStračina, Tiborcs
dc.contributor.authorNováková, Mariecs
dc.contributor.authorJanoušek, Otocs
dc.contributor.authorHejč, Jakubcs
dc.contributor.authorKolářová, Janacs
dc.contributor.authorHlaváčová, Miroslavacs
dc.contributor.authorPaulová, Hanacs
dc.coverage.issue216cs
dc.coverage.volume17cs
dc.date.accessioned2020-08-04T11:00:18Z
dc.date.available2020-08-04T11:00:18Z
dc.date.issued2017-08-09cs
dc.description.abstractDetailed quantitative analysis of the effect of left ventricle (LV) hypertrophy on myocardial ischemia manifestation in ECG is still missing. The associations between both phenomena can be studied in animal models. In this study, rabbit isolated hearts with spontaneously increased LV mass were used to evaluate the effect of such LV alteration on ischemia detection criteria and performance. Electrophysiological effects of increased LV mass were evaluated on sixteen New Zealand rabbit isolated hearts under non-ischemic and ischemic conditions by analysis of various electrogram (EG) parameters. To reveal hearts with increased LV mass, LV weight/heart weight ratio was proposed. Standard paired and unpaired statistical tests and receiver operating characteristics analysis were used to compare data derived from different groups of animals, monitor EG parameters during global ischemia and evaluate their ability to discriminate between unchanged and increased LV as well as non-ischemic and ischemic state. Successful evaluation of both increased LV mass and ischemia is lead-dependent. Particularly, maximal deviation of QRS and area under QRS associated with anterolateral heart wall respond significantly to even early phase (the 1st-3rd min) of ischemia. Besides ischemia, these parameters reflect increased LV mass as well (with sensitivity reaching approx. 80%). However, the sensitivity of the parameters to both phenomena may lead to misinterpretations, when inappropriate criteria for ischemia detection are selected. Particularly, use of cut-off-based criteria defined from control group for ischemia detection in hearts with increased LV mass may result in dramatic reduction (approx. 15%) of detection specificity due to increased number of false positives. Nevertheless, criteria adjusted to particular experimental group allow achieving ischemia detection sensitivity of 89–100% and specificity of 94–100%, respectively. It was shown that response of the heart to myocardial ischemia can be successfully evaluated only when taking into account heart-related factors (such as LV mass) and other methodological aspects (such as recording electrodes position, selected EG parameters, cut-off criteria, etc.). Results of this study might be helpful for developing new clinical diagnostic strategies in order to improve myocardial ischemia detection in patients with LV hypertrophy.en
dc.formattextcs
dc.format.extent1-11cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationBMC Cardiovascular Disorders. 2017, vol. 17, issue 216, p. 1-11.en
dc.identifier.doi10.1186/s12872-017-0652-9cs
dc.identifier.issn1471-2261cs
dc.identifier.other138187cs
dc.identifier.urihttp://hdl.handle.net/11012/69926
dc.language.isoencs
dc.publisherBioMed Centralcs
dc.relation.ispartofBMC Cardiovascular Disorderscs
dc.relation.urihttp://link.springer.com/article/10.1186/s12872-017-0652-9cs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/1471-2261/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectMyocardial ischemia detectionen
dc.subjectincreased left ventricular massen
dc.subjectelectrogramen
dc.subjectROC analysisen
dc.subjectisolated hearten
dc.subjectrabbiten
dc.titleEffect of increased left ventricle mass on ischemia assessment in electrocardiographic signals: rabbit isolated heart studyen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-138187en
sync.item.dbtypeVAVen
sync.item.insts2020.08.04 13:00:18en
sync.item.modts2020.08.04 12:16:17en
thesis.grantorVysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií. Ústav biomedicínského inženýrstvícs
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