Fluorescence study of freeze-drying as a method for support the interactions between hyaluronan and hydrophobic species

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dc.contributor.authorMichalicová, Petracs
dc.contributor.authorMravec, Filipcs
dc.contributor.authorPekař, Miloslavcs
dc.coverage.issue9cs
dc.coverage.volume12cs
dc.date.accessioned2020-08-04T10:59:33Z
dc.date.available2020-08-04T10:59:33Z
dc.date.issued2017-10-03cs
dc.description.abstractA freeze-drying method enabling solubilization of hydrophobic species in aqueous solutions of native hyaluronan is described. The method is based on opening the access to supposed hydrophobic patches on hyaluronan by disturbing its massive hydration shell. Hydrophobic and/or polarity-sensitive fluorescence probes were used as hydrophobic models or indicators of interactions with hydrophobic patches. Fluorescence parameters specific to individual probes confirmed the efficiency of the freeze-drying method. This work is the first step in developing biocompatible and biodegradable carriers for hydrophobic drugs with targeted distribution of the active compound from native, chemically non-modified hyaluronan.en
dc.formattextcs
dc.format.extent1-13cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationPLOS ONE. 2017, vol. 12, issue 9, p. 1-13.en
dc.identifier.doi10.1371/journal.pone.0184558cs
dc.identifier.issn1932-6203cs
dc.identifier.other141013cs
dc.identifier.urihttp://hdl.handle.net/11012/84116
dc.language.isoencs
dc.publisherPLOScs
dc.relation.ispartofPLOS ONEcs
dc.relation.urihttp://europepmc.org/articles/PMC5590968?pdf=rendercs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/1932-6203/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectfluorescenceen
dc.subjectfreeze-dryingen
dc.subjecthyaluronanen
dc.subjectsolubilizationen
dc.titleFluorescence study of freeze-drying as a method for support the interactions between hyaluronan and hydrophobic speciesen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-141013en
sync.item.dbtypeVAVen
sync.item.insts2020.08.04 12:59:33en
sync.item.modts2020.08.04 12:23:51en
thesis.grantorVysoké učení technické v Brně. Fakulta chemická. Centrum materiálového výzkumucs
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