Oriented clonal cell dynamics enables accurate growth and shaping of vertebrate cartilage

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dc.contributor.authorKaiser, Jozefcs
dc.contributor.authorZikmund, Tomášcs
dc.contributor.authorTesařová, Markétacs
dc.coverage.issue4cs
dc.coverage.volume6cs
dc.date.accessioned2020-08-04T11:03:36Z
dc.date.available2020-08-04T11:03:36Z
dc.date.issued2017-04-17cs
dc.description.abstractCartilaginous structures are at the core of embryo growth and shaping before the bone forms. Here we report a novel principle of vertebrate cartilage growth that is based on introducing transversally-oriented clones into pre-existing cartilage. This mechanism of growth uncouples the lateral expansion of curved cartilaginous sheets from the control of cartilage thickness, a process which might be the evolutionary mechanism underlying adaptations of facial shape. In rod-shaped cartilage structures (Meckel, ribs and skeletal elements in developing limbs), the transverse integration of clonal columns determines the well-defined diameter and resulting rod-like morphology. We were able to alter cartilage shape by experimentally manipulating clonal geometries. Using in silico modeling, we discovered that anisotropic proliferation might explain cartilage bending and groove formation at the macro-scale.en
dc.formattextcs
dc.format.extent1-82cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationeLife. 2017, vol. 6, issue 4, p. 1-82.en
dc.identifier.doi10.7554/eLife.25902cs
dc.identifier.issn2050-084Xcs
dc.identifier.other134851cs
dc.identifier.urihttp://hdl.handle.net/11012/65749
dc.language.isoencs
dc.publishereLife Sciences Publicationscs
dc.relation.ispartofeLifecs
dc.relation.urihttps://elifesciences.org/content/6/e25902cs
dc.rightsCreative Commons Public Domain 1.0 Universalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/2050-084X/cs
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/cs
dc.subjectcell dynamicsen
dc.subjectcartilaginous elementsen
dc.subjectgrowthen
dc.subjectcartilageen
dc.titleOriented clonal cell dynamics enables accurate growth and shaping of vertebrate cartilageen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-134851en
sync.item.dbtypeVAVen
sync.item.insts2020.08.04 13:03:36en
sync.item.modts2020.08.04 12:41:21en
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Charakterizace materiálů a pokročilé povlaky 1-06cs
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