Modelové aplikační systémy pro léčiva nerozpustná ve vodě
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B
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Vysoké učení technické v Brně. Fakulta chemická
Abstract
Pomocou metódy UV-VIS spektrofotometrie bola študovaná solubilizačná schopnosť systému micela–hyaluronan. Ako tenzid bol zvolený Septonex a bol použitý hyaluronan o štyroch molekulových hmotnostiach. Solubilizačné pokusy boli vykonané pomocou hydrofóbnych farbív Sudánu Red G a Sudánu III z dôvodu získania modelového systému solubilizovaných liečiv, ktoré sú tiež hydrofóbneho charakteru. Celý systém bol pripravovaný v prostredí mili-Q vody. Bol skúmaný vplyv molekulovej hmotnosti hyaluronanu na solubilizačnú schopnosť. Bolo zistené, že s rastúcou koncentráciou micel rastie aj koncentrácia solubilizovaných farbív a molekulová hmotnosť hyaluronanu má vplyv na rozpustnosť farbív.
The solubilizing capacity of micelle–hyaluronan system was studied using the UV-VIS spectrophotometry method. Septonex was chosen as a surfactant and four molecular weights of hyaluronan were used. Solubilization experiments with a hydrophobic dye Sudan Red G and Sudan III were performed in order to obtain a model system of solubilized drugs, which are also hydrophobic. The system was prepared in the environment of mili-Q water. The influence of the molecular weight of hyaluronan on the solubilizing ability has been studied. It was found that concentration of solubilized dyes increases by increasing concentration of micelles in the system and the molecular weight of hyaluronan affects the solubility of the dyes.
The solubilizing capacity of micelle–hyaluronan system was studied using the UV-VIS spectrophotometry method. Septonex was chosen as a surfactant and four molecular weights of hyaluronan were used. Solubilization experiments with a hydrophobic dye Sudan Red G and Sudan III were performed in order to obtain a model system of solubilized drugs, which are also hydrophobic. The system was prepared in the environment of mili-Q water. The influence of the molecular weight of hyaluronan on the solubilizing ability has been studied. It was found that concentration of solubilized dyes increases by increasing concentration of micelles in the system and the molecular weight of hyaluronan affects the solubility of the dyes.
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Citation
SAPÁROVÁ, A. Modelové aplikační systémy pro léčiva nerozpustná ve vodě [online]. Brno: Vysoké učení technické v Brně. Fakulta chemická. 2015.
Document type
Document version
Date of access to the full text
Language of document
cs
Study field
Chemie pro medicínské aplikace
Comittee
prof. Ing. Miloslav Pekař, CSc. (předseda)
prof. RNDr. Ivana Márová, CSc. (místopředseda)
prof. Ing. Oldřich Zmeškal, CSc. (člen)
prof. Ing. Michal Veselý, CSc. (člen)
doc. Ing. Pavel Diviš, Ph.D. (člen)
Date of acceptance
2015-06-19
Defence
Márová – terminologie - rozpustnost, solubilizace
Veselý – jak se liší Sudan III, Sudan Red G
Result of defence
práce byla úspěšně obhájena
Document licence
Standardní licenční smlouva - přístup k plnému textu bez omezení