The effect of Benzothiazolone-2 on the expression of Metallothionein-3 in modulating Alzheimer's disease
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Metallothioneins (MTs) are a class of ubiquitously occurring low-molecular-weight cysteine- and metal-rich proteins containing sulfur-based metal clusters. MT-3 exhibits neuro-inhibitory activity. The possibility to enhance the expression of MT-3 or protect it from degradation is an attractive therapeutic target, because low levels of MT-3 were found in brains of Alzheimer's disease (AD) patients.
KeywordsAlzheimer’s Disease, Flow Cytometry, Immunodetection, Metallothionein-3, Molecular Dynamics, qRT-PCR
Document typePeer reviewed
Document versionFinal PDF
SourceBrain and Behavior. 2017, vol. 7, issue 9, p. 1-9.