Biotribology of synovial cartilage: Role of albumin in adsorbed film formation

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dc.contributor.authorČípek, Pavelcs
dc.contributor.authorVrbka, Martincs
dc.contributor.authorRebenda, Davidcs
dc.contributor.authorNečas, Davidcs
dc.contributor.authorKřupka, Ivancs
dc.coverage.issue1cs
dc.coverage.volume34cs
dc.date.accessioned2022-02-21T11:53:43Z
dc.date.available2022-02-21T11:53:43Z
dc.date.issued2021-12-23cs
dc.description.abstractA properly lubricated natural synovial joint is the basis of the proper function of the natural musculoskeletal system to lead an active and painless life. A properly lubricated natural synovial joint is the basis of the proper function of the natural movement system to lead an active and painless life. Well lubricated synovial joints are expressed, in particular, by an extremely low coefficient of friction and wear between cartilage surfaces. The presented manuscript is focused on the impact of albumin protein on the formation of adsorbed boundary layer in the contact of cartilage – a simplified model of synovial joint. This can contribute to better understanding of the lubrication in synovial joints. All presented experimental tasks were performed using a reciprocating tribometer along with fluorescence microscopy – friction forces were measured simultaneously with fluorescence records of contact. This unique experimental approach used a newly designed evaluating procedure based on image processing. The experimental results show a great impact of hyaluronic acid; adding of hyaluronic acid leads to a reduction in friction and a larger area of albumin adsorbed boundary layer; however, the phospholipids show the opposite effect. A combination of the individual protein solutions, albumin and c-globulin, has no significant effect on the particles count of albumin clusters adsorbed in the contact; however, the area of albumin adsorbed boundary layer with simple albumin solution was much larger than the solution combining both proteins. The conclusions and discussion of this study describe the role of albumin protein in the lubricating process prevailing in a simplified model of synovial joint under conditions corresponding to slow human gait.en
dc.formattextcs
dc.format.extent1-12cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationEngineering Science and Technology, an International Journal. 2021, vol. 34, issue 1, p. 1-12.en
dc.identifier.doi10.1016/j.jestch.2021.101090cs
dc.identifier.issn2215-0986cs
dc.identifier.other176610cs
dc.identifier.urihttp://hdl.handle.net/11012/203925
dc.language.isoencs
dc.publisherElseviercs
dc.relation.ispartofEngineering Science and Technology, an International Journalcs
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S2215098621002226cs
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivatives 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/2215-0986/cs
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/cs
dc.subjectbiotribologyen
dc.subjectcartilageen
dc.subjectreciprocating tribometeren
dc.subjectfrictionen
dc.subjectlubricationen
dc.subjectfluorescence microscopyen
dc.titleBiotribology of synovial cartilage: Role of albumin in adsorbed film formationen
dc.title.alternativeBiotribologie kloubní chrupavky: Role albuminu v adsorbovaném mazacím filmucs
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-176610en
sync.item.dbtypeVAVen
sync.item.insts2022.11.22 20:56:37en
sync.item.modts2022.11.22 20:14:49en
thesis.grantorVysoké učení technické v Brně. Fakulta strojního inženýrství. Ústav konstruovánícs
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