Consideration of stiffness of wall layers is decisive for patient-specific analysis of carotid artery with atheroma

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dc.contributor.authorLisický, Ondřejcs
dc.contributor.authorMalá, Anetacs
dc.contributor.authorBednařík, Zdeněkcs
dc.contributor.authorNovotný, Tomášcs
dc.contributor.authorBurša, Jiřícs
dc.coverage.issue9cs
dc.coverage.volume15cs
dc.date.accessioned2021-04-22T10:54:15Z
dc.date.available2021-04-22T10:54:15Z
dc.date.issued2020-09-29cs
dc.description.abstractThe paper deals with the impact of chosen geometric and material factors on maximal stresses in carotid atherosclerotic plaque calculated using patient-specific finite element models. These stresses are believed to be decisive for the plaque vulnerability but all applied models suffer from inaccuracy of input data, especially when obtainedin vivoonly. One hundred computational models based onex vivoMRI are used to investigate the impact of wall thickness, MRI slice thickness, lipid core and fibrous tissue stiffness, and media anisotropy on the calculated peak plaque and peak cap stresses. The investigated factors are taken as continuous in the range based on published experimental results, only the impact of anisotropy is evaluated by comparison with a corresponding isotropic model. Design of Experiment concept is applied to assess the statistical significance of these investigated factors representing uncertainties in the input data of the model. The results show that consideration of realistic properties of arterial wall in the model is decisive for the stress evaluation; assignment of properties of fibrous tissue even to media and adventitia layers as done in some studies may induce up to eightfold overestimation of peak stress. The impact of MRI slice thickness may play a key role when local thin fibrous cap is present. Anisotropy of media layer is insignificant, and the stiffness of fibrous tissue and lipid core may become significant in some combinations.en
dc.formattextcs
dc.format.extent1-18cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationPLOS ONE. 2020, vol. 15, issue 9, p. 1-18.en
dc.identifier.doi10.1371/journal.pone.0239447cs
dc.identifier.issn1932-6203cs
dc.identifier.other165769cs
dc.identifier.urihttp://hdl.handle.net/11012/196570
dc.language.isoencs
dc.publisherPLOScs
dc.relation.ispartofPLOS ONEcs
dc.relation.urihttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0239447cs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/1932-6203/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectBIAXIAL MECHANICAL-PROPERTIESen
dc.subjectFIBROUS CAP THICKNESSen
dc.subjectIN-VIVOen
dc.subjectATHEROSCLEROTIC PLAQUESen
dc.subjectSTRESSen
dc.subjectMODELen
dc.subjectMICROCALCIFICATIONSen
dc.subjectRESOLUTIONen
dc.subjectSTRAINen
dc.subjectINTACTen
dc.titleConsideration of stiffness of wall layers is decisive for patient-specific analysis of carotid artery with atheromaen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-165769en
sync.item.dbtypeVAVen
sync.item.insts2021.04.22 12:54:15en
sync.item.modts2021.04.22 12:15:06en
thesis.grantorVysoké učení technické v Brně. Fakulta strojního inženýrství. Ústav mechaniky těles, mechatroniky a biomechanikycs
thesis.grantorVysoké učení technické v Brně. . Ústav přístrojové techniky AV ČRcs
thesis.grantorVysoké učení technické v Brně. . Fakultní nemocnice u sv. Anny v Brněcs
thesis.grantorVysoké učení technické v Brně. . Lékařská fakultacs
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