G4Killer web application: a tool to design G-quadruplex mutations

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dc.contributor.authorBrázda, Václavcs
dc.contributor.authorKolomazník, Jancs
dc.contributor.authorMergny, Jean-Louiscs
dc.contributor.authorŠťastný, Jiřícs
dc.coverage.issue10cs
dc.coverage.volume36cs
dc.date.accessioned2020-08-27T20:58:50Z
dc.date.available2020-08-27T20:58:50Z
dc.date.issued2020-05-15cs
dc.description.abstractG-quadruplexes (G4) are important regulatory non-B DNA structures with therapeutic potential. A tool for rational design of mutations leading to decreased propensity for G4 formation should be useful in studying G4 functions. Although tools exist for G4 prediction, no easily accessible tool for the rational design of G4 mutations has been available. RESULTS: We developed a web-based tool termed G4Killer that is based on the G4Hunter algorithm. This new tool is a platform-independent and user-friendly application to design mutations crippling G4 propensity in a parsimonious way (i.e., keeping the primary sequence as close as possible to the original one). The tool is integrated into our DNA analyzer server and allows for generating mutated DNA sequences having the desired lowered G4Hunter score with minimal mutation steps. AVAILABILITY AND IMPLEMENTATION: The G4Killer web tool can be accessed at: http://bioinformatics.ibp.cz. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online. © The Author(s) 2020. Published by Oxford University Press.en
dc.formattextcs
dc.format.extent3246-3247cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationBIOINFORMATICS. 2020, vol. 36, issue 10, p. 3246-3247.en
dc.identifier.doi10.1093/bioinformatics/btaa057cs
dc.identifier.issn1367-4803cs
dc.identifier.other164187cs
dc.identifier.urihttp://hdl.handle.net/11012/194871
dc.language.isoencs
dc.relation.ispartofBIOINFORMATICScs
dc.relation.urihttps://academic.oup.com/bioinformatics/article/36/10/3246/5716328cs
dc.rightsCreative Commons Attribution-NonCommercial 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/1367-4803/cs
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/cs
dc.subjectG4Killeren
dc.subjectG-quadruplexen
dc.subjectweb applicationen
dc.titleG4Killer web application: a tool to design G-quadruplex mutationsen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-164187en
sync.item.dbtypeVAVen
sync.item.insts2020.08.27 22:58:50en
sync.item.modts2020.08.27 08:18:51en
thesis.grantorVysoké učení technické v Brně. Fakulta strojního inženýrství. Ústav automatizace a informatikycs
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